Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket
نویسندگان
چکیده
منابع مشابه
Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket
The stress-inducible mammalian heat shock protein 70 (HSP70) and its bacterial orthologue DnaK are highly conserved nucleotide binding molecular chaperones. They represent critical regulators of cellular proteostasis, especially during conditions of enhanced stress. Cancer cells rely on HSP70 for survival, and this chaperone represents an attractive new therapeutic target. We have used a struct...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2020
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2020.01.009